- Rune 2
- Rune Factory 2: A Fantasy Harvest Moon
- Rune Factory 3: A Fantasy Harvest Moon
- Rune Factory 3 Special
- Rune Factory 4
- Rune Factory 5
- Rune Factory: Frontier
- Rune Factory: Tides of Destiny
- Runemaster
- Runes of Magic
- RuneScape
- RuneScape: Idle Adventures
- Runespell: Overture
- Runner3
- Running Shadow
- RunSanity
- Rush Bros.
- Rush Horizon
- Rush Rush Rally Racing
- Rush'n Attack: Ex-Patriot
- Russian Fishing 4
- Rust
- Rustbucket Rumble
- Rustler
- Rusty Hearts
- Ruzar: The Life Stone
- Ruzzle Adventure
- RWBY: Arrowfell
- RWBY: Grimm Eclipse
- Rymdkapsel
- Ryse: Son of Rome
- Ryse: Son of Rome - Morituri Pack
- S.T.A.L.K.E.R. 2: Heart of Chornobyl
- S.T.A.L.K.E.R.: Call of Pripyat
- S.T.A.L.K.E.R.: Clear Sky
- S.T.A.L.K.E.R.: Shadow of Chernobyl
- S.W.A.N.: Chernobyl Unexplored
- S4 League
- Saban's Power Rangers Super Megaforce
- Saboteur, The
- Sackboy: A Big Adventure
- Sacraboar
- Sacred 2: Fallen Angel
- Sacred 3
- Sacred Citadel
- Sacred Legends
- Sacred Tears True, The
- Saga
- SaGa 3 Jikū no Hasha: Shadow or Light
- SaGa Frontier Remastered
- SAGA Online
- Sail Forth
- Sail Simulator 2010
- Saint Kotar
- Saint Seiya: Brave Soldiers
- Saint Seiya Omega: Ultimate Cosmo
- Saint Seiya Senki
- Saint Seiya: Soldiers' Soul - Knights of the Zodiac
- Saints Row 2
- Saints Row 4
- Saints Row 4: Enter the Dominatrix
- Saints Row 4: How the Saints Save Christmas
- Saints Row 4: National Treasure Edition
- Saints Row 4: Re-Elected
- Saints Row: Gat Out of Hell
- Saints Row [I/2006]
- Saints Row [II/2022]
- Saints Row: The Third
- Saints Row: The Third Remastered
- Saira
- Sakuna: Of Rice and Ruin
- Sakura Spirit
- Salem
- Sally's Spa
- Salt and Sanctuary
- Sam & Max Beyond Time and Space Remastered
- Sam & Max: Episode 202 - Moai Better Blues
- Sam & Max: Episode 203 - Night of the Raving Dead
- Sam & Max: Episode 204 - Chariots of the Dogs
- Sam & Max: Episode 205 - What's New, Beelzebub?
- Sam & Max Save the World Remastered
- Sam & Max Season 2
- Sam & Max: The Devil's Playhouse - Episode 1: The Penal Zone
- Sam & Max: This Time It’s Virtual
- Samantha Swift and the Hidden Roses of Athena
- Samorost 3
- Samudai
- Samurai & Dragons
- Samurai Gunn 2
- Samurai Jack: Battle Through Time
- Samurai Maiden
- Samurai Shodown 2
- Samurai Shodown NeoGeo Collection
- Samurai Shodown: Sen
- Samurai Siege
- Samurai Warriors 2
- Samurai Warriors 3
- Samurai Warriors 4
- Samurai Warriors 4-2
- Samurai Warriors 4: Empires