- Rugby League Team Manager 3
- Rugby Union Team Manager 3
- Ruiner
- Run Rabbit Run
- Runaway Express Mystery
- Runemaster
- RuneScape: Idle Adventures
- Runespell: Overture
- Runestone Keeper
- RunGunJumpGun
- Runner3
- Running with Rifles
- Running with Rifles: Pacific
- Rush Bros.
- Russian Front
- Rust
- Rustbucket Rumble
- Rustler
- Ruzar: The Life Stone
- RWBY: Grimm Eclipse
- Rymdkapsel
- RymdResa
- Sacred Almanac: Traces of Greed
- Sacrilegium
- Saga of Sins
- Saga of the North Wind
- Sagebrush
- Sail Forth
- Sakura Spirit
- Sally's Spa
- Salt and Sanctuary
- Saltsea Chronicles
- Sam & Max: The Devil's Playhouse - Episode 1: The Penal Zone
- Sam & Max: The Devil's Playhouse - Episode 2: The Tomb of Sammun-Mak
- Sam & Max: The Devil's Playhouse - Episode 3: They Stole Max's Brain!
- Sam & Max: The Devil's Playhouse - Episode 4: Beyond the Alley of the Dolls
- Sam & Max: The Devil's Playhouse - Episode 5: The City That Dares Not Sleep
- Samorost 2
- Samorost 3
- Samsara
- Samurai 2: Vengeance
- Samurai Shodown 2
- Samurai Shodown 5 Special
- Sanctum [II/2011]
- Sandbox, The
- Sandwalkers
- Sanity of Morris
- Santa's Special Delivery
- Santa's Workshop
- Satellite Reign
- Saturday Morning RPG
- Saturnalia
- Sausage Sports Club
- Savage 2: Tortured Soul
- Savant: Ascent
- Save Koch
- Save the Ninja Clan
- Savior
- Say No! More
- Sayonara Wild Hearts
- SCALE
- Scarab Tales
- Scarlet Hood and the Wicked Wood
- School 26
- Science Girls!
- Scoregasm
- Scott in Space
- Scourge: Outbreak
- ScourgeBringer
- Screencheat
- Scrolls
- Scythe: Digital Edition
- SeaCraft
- Seasons After Fall
- Second Chance Heroes
- Second Warfare
- Secret Government
- Secret Journeys: Cities of the World
- Secret of Monkey Island: Special Edition, The
- Secret of Tremendous Corporation, The
- Secret Order 2: Masked Intent, The
- Secrets of Rætikon
- Secrets of the Vatican: The Holy Lance
- Selknam Defense
- Semblance
- Sensational World Soccer 2010
- Sense – 不祥的预感: A Cyberpunk Ghost Story
- Sentinel
- Sentinel 3: Homeworld
- Sentinels of the Multiverse: The Video Game
- Serena
- Serial Cleaner
- Serious Sam 3: BFE
- Serpent in the Staglands
- Serpent of Isis, The
- Servo
- Settlers 2, The
- Settlers 7: Paths to a Kingdom, The
- SEUM: Speedrunners from Hell
- Seven Dragon Saga